Physical processes leading to surface inhomogeneities: the case of rotation

In this lecture I discuss the bulk surface heterogeneity of rotating stars, namely gravity darkening. I especially detail the derivation of the omega-model of Espinosa Lara & Rieutord (2011), which gives the gravity darkening in early-type stars. I also discuss the problem of deriving gravity darkening in stars owning a convective envelope and in those that are members of a binary system.Comment: 23 pages, 11 figure, Lecture given to the school on the cartography of the Sun and the stars (May 2014 in Besan\c{c}on), to appear in LNP, Neiner and Rozelot edts V2: typos correcte

A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells

Mannose 6-phosphate receptors (MPRs) are transported from endosomes to the Golgi after delivering lysosomal enzymes to the endocytic pathway. This process requires Rab9 guanosine triphosphatase (GTPase) and the putative tether GCC185. We show in human cells that a soluble NSF attachment protein receptor (SNARE) complex comprised of syntaxin 10 (STX10), STX16, Vti1a, and VAMP3 is required for this MPR transport but not for the STX6-dependent transport of TGN46 or cholera toxin from early endosomes to the Golgi. Depletion of STX10 leads to MPR missorting and hypersecretion of hexosaminidase. Mouse and rat cells lack STX10 and, thus, must use a different target membrane SNARE for this process. GCC185 binds directly to STX16 and is competed by Rab6. These data support a model in which the GCC185 tether helps Rab9-bearing transport vesicles deliver their cargo to the trans-Golgi and suggest that Rab GTPases can regulate SNARE–tether interactions. Importantly, our data provide a clear molecular distinction between the transport of MPRs and TGN46 to the trans-Golgi

“The feeling of fear was not from my student, but from myself”: A pre-service teacher’s shift from traditional to problem-posing second language pedagogy in a Mexican youth prison

This era of globalization, capitalism, and economic progress has given rise to mass incarceration, as a considerable number of youths in developing and developed countries live behind bars in detention facilities without appropriate educational support. Educators in these facilities deposit knowledge, through traditional pedagogical approaches, under systemic oppression and surveillance deemed necessary for safety and security. This study investigated implementations of Freire’s (2000) problem-posing pedagogy using a participatory action research (PAR) approach through the lens of critical theory. Two of the co-authors helped develop a Freirean language teaching program in an urban youth prison in Mexico, centering student teachers’ critical self-awareness by providing them with opportunities to reflect on their identity, life experiences, and reality while teaching in prison. Through critical, autoethnographic self-reflections of a bilingual teacher candidate on her teaching practices, this study provides insights into how the teacher was impacted by the problem-posing pedagogy and how it was reflected in her transformation to a critical, loving teacher and student progress. This research embraces a humanistic approach to teaching incarcerated youth in Mexico through care and courage by supporting them as students, as well as by empowering their voices and thoughts. Building a learning community, where students and teachers create respectful human connections through dialogue and discussions on language, culture, and lived experiences, is portrayed in this research as essential

Unveiling interactions between DNA and cytotoxic 2-arylpiperidinyl-1,4-naphthoquinone derivatives: A combined electrochemical and computational study

Indexación: Scopus.Three 2-arylpiperidinyl-1,4-naphthoquinone derivatives were synthesized and evaluated in vitro to determine their cytotoxicity on cancer and normal cell lines. In order to establish their possible action mechanism, the electrochemical behaviour of these quinones was examined using cyclic voltammetry (CV) as technique by using a three-electrode setup: a glassy carbon, Ag/AgCl (in 3 M KCl), and platinum wire as working, reference, and counter electrodes, respectively. Kinetic studies were done to determine the control of the reduction reaction and the number of transferred electrons in the process. Furthermore, the addition of dsDNA to the quinone solutions allowed for the observation of an interaction between each quinone and dsDNA as the current-peaks became lower in presence of dsDNA. Otherwise, motivated to support the aforementioned results, electronic structure calculations at the TPSS-D3/6-31+G(d,p) level of theory were carried out in order to find the most favourable noncovalently bonded complexes between quinones and DNA. Noncovalent complexes formed between DNA and 2-arylpiperidinyl-1,4-naphthoquinones and stabilized by π-stacking interactions along with the well-known hydrogen-bonded complexes were found, with the former being more stable than the latter. These results suggest that the intercalation of these quinone derivatives in DNA is the most likely action mechanism. © 2018 King Saud Universityhttps://www.sciencedirect.com/science/article/pii/S1878535218300893?via%3Dihu